Frontiers in Neurology (Nov 2020)
Applications of Non-invasive Neuromodulation for the Management of Disorders Related to COVID-19
- Abrahão Fontes Baptista,
- Abrahão Fontes Baptista,
- Abrahão Fontes Baptista,
- Abrahão Fontes Baptista,
- Adriana Baltar,
- Adriana Baltar,
- Alexandre Hideki Okano,
- Alexandre Hideki Okano,
- Alexandre Hideki Okano,
- Alexandre Hideki Okano,
- Alexandre Moreira,
- Ana Carolina Pinheiro Campos,
- Ana Mércia Fernandes,
- André Russowsky Brunoni,
- André Russowsky Brunoni,
- Bashar W. Badran,
- Clarice Tanaka,
- Clarice Tanaka,
- Clarice Tanaka,
- Daniel Ciampi de Andrade,
- Daniel Ciampi de Andrade,
- Daniel Gomes da Silva Machado,
- Edgard Morya,
- Eduardo Trujillo,
- Eduardo Trujillo,
- Jaiti K. Swami,
- Joan A. Camprodon,
- Katia Monte-Silva,
- Katia Monte-Silva,
- Katia Nunes Sá,
- Katia Nunes Sá,
- Isadora Nunes,
- Juliana Barbosa Goulardins,
- Juliana Barbosa Goulardins,
- Juliana Barbosa Goulardins,
- Juliana Barbosa Goulardins,
- Marom Bikson,
- Pedro Sudbrack-Oliveira,
- Priscila de Carvalho,
- Rafael Jardim Duarte-Moreira,
- Rafael Jardim Duarte-Moreira,
- Rosana Lima Pagano,
- Samuel Katsuyuki Shinjo,
- Yossi Zana
Affiliations
- Abrahão Fontes Baptista
- Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil
- Abrahão Fontes Baptista
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Abrahão Fontes Baptista
- Brazilian Institute of Neuroscience and Neurotechnology Centros de Pesquisa, Investigação e Difusão - Fundação de Amparo à Pesquisa do Estado de São Paulo (BRAINN/CEPID-FAPESP), University of Campinas, Campinas, Brazil
- Abrahão Fontes Baptista
- Laboratory of Medical Investigations 54 (LIM-54), São Paulo University, São Paulo, Brazil
- Adriana Baltar
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Adriana Baltar
- Specialized Neuromodulation Center—Neuromod, Recife, Brazil
- Alexandre Hideki Okano
- Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil
- Alexandre Hideki Okano
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Alexandre Hideki Okano
- Brazilian Institute of Neuroscience and Neurotechnology Centros de Pesquisa, Investigação e Difusão - Fundação de Amparo à Pesquisa do Estado de São Paulo (BRAINN/CEPID-FAPESP), University of Campinas, Campinas, Brazil
- Alexandre Hideki Okano
- Graduate Program in Physical Education, State University of Londrina, Londrina, Brazil
- Alexandre Moreira
- School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil
- Ana Carolina Pinheiro Campos
- Laboratory of Neuroscience, Hospital Sirio-Libanes, São Paulo, Brazil
- Ana Mércia Fernandes
- Centro de Dor, LIM-62, Departamento de Neurologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
- André Russowsky Brunoni
- 0Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Instituto Nacional de Biomarcadores em Neuropsiquiatria, São Paulo, Brazil
- André Russowsky Brunoni
- 1Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
- Bashar W. Badran
- 2Department of Psychiatry, Medical University of South Carolina, Charleston, SC, United States
- Clarice Tanaka
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Clarice Tanaka
- Laboratory of Medical Investigations 54 (LIM-54), São Paulo University, São Paulo, Brazil
- Clarice Tanaka
- 3Instituto Central, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
- Daniel Ciampi de Andrade
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Daniel Ciampi de Andrade
- Centro de Dor, LIM-62, Departamento de Neurologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
- Daniel Gomes da Silva Machado
- 4Graduate Program in Collective Health, Federal University of Rio Grande do Norte, Natal, Brazil
- Edgard Morya
- 5Edmond and Lily Safra International Neuroscience Institute, Santos Dumont Institute, Macaiba, Brazil
- Eduardo Trujillo
- Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil
- Eduardo Trujillo
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Jaiti K. Swami
- 6Department of Biomedical Engineering, The City College of New York of CUNY, New York, NY, United States
- Joan A. Camprodon
- 7Laboratory for Neuropsychiatry and Neuromodulation, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
- Katia Monte-Silva
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Katia Monte-Silva
- 8Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Recife, Brazil
- Katia Nunes Sá
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Katia Nunes Sá
- 9Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil
- Isadora Nunes
- 0Department of Physiotherapy, Pontifícia Universidade Católica de Minas Gerais, Betim, Brazil
- Juliana Barbosa Goulardins
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Juliana Barbosa Goulardins
- Laboratory of Medical Investigations 54 (LIM-54), São Paulo University, São Paulo, Brazil
- Juliana Barbosa Goulardins
- School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil
- Juliana Barbosa Goulardins
- 1Universidade Cruzeiro do Sul (UNICSUL), São Paulo, Brazil
- Marom Bikson
- 6Department of Biomedical Engineering, The City College of New York of CUNY, New York, NY, United States
- Pedro Sudbrack-Oliveira
- 2Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
- Priscila de Carvalho
- 3Instituto Central, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
- Rafael Jardim Duarte-Moreira
- Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil
- Rafael Jardim Duarte-Moreira
- NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil
- Rosana Lima Pagano
- Laboratory of Neuroscience, Hospital Sirio-Libanes, São Paulo, Brazil
- Samuel Katsuyuki Shinjo
- 3Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
- Yossi Zana
- Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil
- DOI
- https://doi.org/10.3389/fneur.2020.573718
- Journal volume & issue
-
Vol. 11
Abstract
Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19.Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders.Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders.Results: Non-invasive neuromodulation may manage disorders associated with COVID-19 through four pathways: (1) Direct infection mitigation through the stimulation of regions involved in the regulation of systemic anti-inflammatory responses and/or autonomic responses and prevention of neuroinflammation and recovery of respiration; (2) Amelioration of COVID-19 symptoms of musculoskeletal pain and systemic fatigue; (3) Augmenting cognitive and physical rehabilitation following critical illness; and (4) Treating outbreak-related mental distress including neurological and psychiatric disorders exacerbated by surrounding psychosocial stressors related to COVID-19. The selection of the appropriate techniques will depend on the identified target treatment pathway.Conclusion: COVID-19 infection results in a myriad of acute and chronic symptoms, both directly associated with respiratory distress (e.g., rehabilitation) or of yet-to-be-determined etiology (e.g., fatigue). Non-invasive neuromodulation is a toolbox of techniques that based on targeted pathways and empirical evidence (largely in non-COVID-19 patients) can be investigated in the management of patients with COVID-19.
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