mSphere
(Jun 2021)
Enterococcal PrgU Provides Additional Regulation of Pheromone-Inducible Conjugative Plasmids
Lena Lassinantti,
Martha I. Camacho,
Rebecca J. B. Erickson,
Julia L. E. Willett,
Nicholas R. De Lay,
Josy ter Beek,
Gary M. Dunny,
Peter J. Christie,
Ronnie P.-A. Berntsson
Affiliations
Lena Lassinantti
ORCiD Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
Martha I. Camacho
Department of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA
Rebecca J. B. Erickson
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Julia L. E. Willett
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Nicholas R. De Lay
Department of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA
Josy ter Beek
ORCiD Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
Gary M. Dunny
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Peter J. Christie
Department of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA
Ronnie P.-A. Berntsson
ORCiD Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
DOI
https://doi.org/10.1128/mSphere.00264-21
Journal volume & issue
Vol. 6,
no. 3
Abstract
Read online
Bacteria utilize type 4 secretion systems (T4SS) to efficiently transfer DNA between donor and recipient cells, thereby spreading genes encoding antibiotic resistance as well as various virulence factors. Regulation of expression of the T4SS proteins and surface adhesins in Gram-positive bacteria is crucial, as some of these are highly toxic to the cell.
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