Frontiers in Neurology (Mar 2024)

Altered volume of the amygdala subregions in patients with chronic low back pain

  • Si-Yu Gu,
  • Feng-Chao Shi,
  • Shu Wang,
  • Cheng-Yu Wang,
  • Xin-Xin Yao,
  • Yi-Fan Sun,
  • Jian-Bin Hu,
  • Fei Chen,
  • Ping-Lei Pan,
  • Wen-Hui Li

DOI
https://doi.org/10.3389/fneur.2024.1351335
Journal volume & issue
Vol. 15

Abstract

Read online

BackgroundNeuroimaging studies have suggested a pivotal role for the amygdala involvement in chronic low back pain (CLBP). However, the relationship between the amygdala subregions and CLBP has not yet been delineated. This study aimed to analyze whether the amygdala subregions were linked to the development of CLBP.MethodsA total of 45 patients with CLBP and 45 healthy controls (HCs) were included in this study. All subjects were asked to complete a three-dimensional T1-weighted magnetic resonance imaging (3D-T1 MRI) scan. FreeSurfer 7.3.2 was applied to preprocess the structural MRI images and segment the amygdala into nine subregions. Afterwards, comparisons were made between the two groups in terms of the volumes of the amygdala subregions. Correlation analysis is utilized to examine the relationship between the amygdala subregion and the scale scores, as well as the pain duration in patients with CLBP. Additionally, logistic regression was used to explore the risk of the amygdala and its subregions for CLBP.ResultsIn comparison to HCs, patients with CLBP exhibited a significant enlargement of the left central nucleus (Ce) and left cortical nucleus (Co). Furthermore, the increased volume of the left Ce was associated with a higher risk of CLBP.ConclusionOur study suggests that the left Ce and left Co may be involved in the pathophysiological processes of CLBP. Moreover, the volume of the left Ce may be a biomarker for detecting the risk of CLBP.

Keywords