This paper presents a high precision adaptive slope compensation circuit for for DC -DC converter in wearable devices. Compared with the traditional adaptive slope compensation circuit, the comparator is used to sample the output voltage and input voltage, which greatly improves the accuracy.ln this paper, the circuit is designed in UMC 0.18-p,m CMOS Technology and verified by Virtuoso Spectre Circuit Simulator. The simulation results show that the accuracy of the adaptive slope compensation circuit in this paper can reach more than 96%.