Nature Communications (Jan 2020)

Siah2 control of T-regulatory cells limits anti-tumor immunity

  • Marzia Scortegagna,
  • Kathryn Hockemeyer,
  • Igor Dolgalev,
  • Joanna Poźniak,
  • Florian Rambow,
  • Yan Li,
  • Yongmei Feng,
  • Roberto Tinoco,
  • Dennis C. Otero,
  • Tongwu Zhang,
  • Kevin Brown,
  • Marcus Bosenberg,
  • Linda M. Bradley,
  • Jean-Christophe Marine,
  • Ioannis Aifantis,
  • Ze’ev A. Ronai

DOI
https://doi.org/10.1038/s41467-019-13826-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressive regulatory T cells, resulting in inhibition of tumour growth.