Nature Communications (Jan 2020)
Siah2 control of T-regulatory cells limits anti-tumor immunity
Abstract
The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressive regulatory T cells, resulting in inhibition of tumour growth.