Objective: To investigate the effect of uterine artery embolization (UAE) in the treatment of symptomatic uterine fibroids and the effect on ovarian function. Methods: Clinical data of 20 UAE cases admitted from August 2014 to August 2015 were retrospectively analyzed. They had uterine leiomyoma, and received UAE after menstruation 3-7 d. Seldinger technology was used to puncture the right femoral artery, microspheres was alginated or polyvinyl alcohol particles were injected into the target vessel embolism vascular leiomyoma. Broken Gelfoam embolization of uterine artery was used to stop fibroids blood supply; imaging examination of symptomatic uterine fibroids was performed before and 3 months, 6 months, 12 months after UAE. The volume of uterus myoma volume changes was observed; luteinizing hormone (LH), prolactin (PRL), follicle stimulating hormone (FSH), progesterone (PROG), estradiol (E2) changes were detected before and 3 months, 6 months, 12 months after UAE. Results: Three months, 6 months, 12 months after UAE surgery, all patients were followed up for 3 months. The volume of uterus and tumor volume were significantly reduced, and the degree of reduction was moresignificant (P0.05). Conclusions: UAE has definite efficacy, and it has little effect on ovarian function.