PLoS Neglected Tropical Diseases (Apr 2020)

Non-typhoidal Salmonella bloodstream infections in Kisantu, DR Congo: Emergence of O5-negative Salmonella Typhimurium and extensive drug resistance.

  • Bieke Tack,
  • Marie-France Phoba,
  • Barbara Barbé,
  • Lisette M Kalonji,
  • Liselotte Hardy,
  • Sandra Van Puyvelde,
  • Brecht Ingelbeen,
  • Dadi Falay,
  • Dauly Ngonda,
  • Marianne A B van der Sande,
  • Stijn Deborggraeve,
  • Jan Jacobs,
  • Octavie Lunguya

DOI
https://doi.org/10.1371/journal.pntd.0008121
Journal volume & issue
Vol. 14, no. 4
p. e0008121

Abstract

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BackgroundNon-typhoidal Salmonella (NTS) are a major cause of bloodstream infection (BSI) in sub-Saharan Africa. This study aimed to assess its longitudinal evolution as cause of BSI, its serotype distribution and its antibiotic resistance pattern in Kisantu, DR Congo.MethodsAs part of a national surveillance network, blood cultures were sampled in patients with suspected BSI admitted to Kisantu referral hospital from 2015-2017. Blood cultures were worked-up according to international standards. Results were compared to similar data from 2007 onwards.ResultsIn 2015-2017, NTS (n = 896) represented the primary cause of BSI. NTS were isolated from 7.6% of 11,764 suspected and 65.4% of 1371 confirmed BSI. In children ConclusionAs in previous surveillance periods, NTS ranked first as the cause of BSI in children. The emergence of O5-negative Salmonella Typhimurium needs to be considered in the light of vaccine development. The high proportions of antibiotic resistance are worrisome.