Skin sensitization evaluation of a flavanol from processed rose wastewater for cosmetic application

Abstract

Flavanols are extremely relevant for application and study due to the beneficial effect they have for humans when used internally or externally. They are identified in almost all plant cultures, as their metabolic products. Their pronounced benefit for protecting and restoring the skin in case of mechanical damage, radiation, allergens, chemicals and infections has been proven. Due to their natural origin, their dermatological application is also preferred. In such a case, the action of the chemical compounds and the generated skin metabolites have different mechanisms of action with respect to DNA and binding to proteins. The preliminary assessment of skin sensitization is a complex and lengthy task. Depending on the results, it is necessary to have an efficient technological approach for the isolation of flavanols with skin sensitization. Evaluation of the probable skin metabolic activity of cosmetic products containing flavanol (Luteolin) from processed rose wastewater is the aim of the conducted research, as well as prediction of protein and DNA binding of its metabolites by in silico methods (OECD QSAR Toolbox). The parent structure of the compound, as well as some of its generated metabolites, exhibit reactivity, i.e. they have different mechanisms of action in terms of DNA and protein binding.