Biology (Jun 2022)

MAGE: An Open-Source Tool for Meta-Analysis of Gene Expression Studies

  • Ioannis A. Tamposis,
  • Georgios A. Manios,
  • Theodosia Charitou,
  • Konstantina E. Vennou,
  • Panagiota I. Kontou,
  • Pantelis G. Bagos

DOI
https://doi.org/10.3390/biology11060895
Journal volume & issue
Vol. 11, no. 6
p. 895

Abstract

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MAGE (Meta-Analysis of Gene Expression) is a Python open-source software package designed to perform meta-analysis and functional enrichment analysis of gene expression data. We incorporate standard methods for the meta-analysis of gene expression studies, bootstrap standard errors, corrections for multiple testing, and meta-analysis of multiple outcomes. Importantly, the MAGE toolkit includes additional features for the conversion of probes to gene identifiers, and for conducting functional enrichment analysis, with annotated results, of statistically significant enriched terms in several formats. Along with the tool itself, a web-based infrastructure was also developed to support the features of this package.

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