Chemoproteomic discovery of a human RNA ligase

Yizhi Yuan; Florian M. Stumpf; Lisa A. Schlor; Olivia P. Schmidt; Philip Saumer; Luisa B. Huber; Matthias Frese; Eva Höllmüller; Martin Scheffner; Florian Stengel; Kay Diederichs; Andreas Marx

doi:10.1038/s41467-023-36451-x

Nature Communications (Feb 2023)

Chemoproteomic discovery of a human RNA ligase

Yizhi Yuan,
Florian M. Stumpf,
Lisa A. Schlor,
Olivia P. Schmidt,
Philip Saumer,
Luisa B. Huber,
Matthias Frese,
Eva Höllmüller,
Martin Scheffner,
Florian Stengel,
Kay Diederichs,
Andreas Marx

Affiliations

Yizhi Yuan: Department of Chemistry, University of Konstanz
Florian M. Stumpf: Department of Chemistry, University of Konstanz
Lisa A. Schlor: Department of Chemistry, University of Konstanz
Olivia P. Schmidt: Department of Chemistry, University of Konstanz
Philip Saumer: Department of Chemistry, University of Konstanz
Luisa B. Huber: Department of Chemistry, University of Konstanz
Matthias Frese: Department of Chemistry, University of Konstanz
Eva Höllmüller: Department of Chemistry, University of Konstanz
Martin Scheffner: Konstanz Research School Chemical Biology, University of Konstanz
Florian Stengel: Konstanz Research School Chemical Biology, University of Konstanz
Kay Diederichs: Konstanz Research School Chemical Biology, University of Konstanz
Andreas Marx: Department of Chemistry, University of Konstanz

DOI: https://doi.org/10.1038/s41467-023-36451-x
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

Read online

RNA ligases are present across all forms of life. Here, the hitherto uncharacterised human protein C12orf29 was identified as a human enzyme promoting RNA ligation between 5′-PO4 and 3′-OH termini. This data provides the groundwork for establishing a human RNA repair pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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