Synthetic effect of folate deficiency, low expression of hnRNP E2 and down-regulation of HPV16 L1 and L2 proteins on cervical intraepithelial neoplasia: A cross-sectional study based on a Chinese community

Abstract

To evaluate the effects and interactions of these factors in CIN in a Chinese cohort. A total of 180 participants, including 61 normal cervix (NC), 59 CIN-I, and 60 CIN-II/III women were enrolled. We measured the serum folate, expressions of hnRNP E2, HPV16 L1, and L2 protein. The levels of serum folate in CIN-I and CIN-II/III groups were lower than the NC group. The expression of hnRNP E2 in the CIN-Ⅱ/Ⅲ group was significantly lower than the NC group (P < 0.001). The expressions of HPV16 L1 (P < 0.0167) and L2 (P < 0.001) proteins in the CIN-Ⅱ/Ⅲ group were significantly lower than the CIN-Ⅰ group. Folate deficiency, low expression of hnRNP E2, down-regulation of HPV16 L1 and L2 proteins presented interaction effects both in CIN-I and CIN-II/III groups. Their synthetic effect could promote the process of the cervical lesions into a high-grade CC development.

Keywords

• Folate
• Heterogeneous nuclear ribonucleoprotein (hnRNP) E2
• HPV16 L1 protein
• HPV16 L2 protein
• Cervical intraepithelial neoplasia (CIN)