Nature Communications (Sep 2021)
The gut microbiome in konzo
- Matthew S. Bramble,
- Neerja Vashist,
- Arthur Ko,
- Sambhawa Priya,
- Céleste Musasa,
- Alban Mathieu,
- D’ Andre Spencer,
- Michel Lupamba Kasendue,
- Patrick Mamona Dilufwasayo,
- Kevin Karume,
- Joanna Nsibu,
- Hans Manya,
- Mary N. A. Uy,
- Brian Colwell,
- Michael Boivin,
- J. P. Banae Mayambu,
- Daniel Okitundu,
- Arnaud Droit,
- Dieudonné Mumba Ngoyi,
- Ran Blekhman,
- Desire Tshala-Katumbay,
- Eric Vilain
Affiliations
- Matthew S. Bramble
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- Neerja Vashist
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- Arthur Ko
- Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles
- Sambhawa Priya
- Departments of Genetics, Cell Biology, and Development, University of Minnesota
- Céleste Musasa
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- Alban Mathieu
- Computational Biology Laboratory, CHU de Québec - Université Laval Research Center
- D’ Andre Spencer
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- Michel Lupamba Kasendue
- Institut National de Recherche Biomédicale (INRB)
- Patrick Mamona Dilufwasayo
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- Kevin Karume
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- Joanna Nsibu
- Institut National de Recherche Biomédicale (INRB)
- Hans Manya
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- Mary N. A. Uy
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- Brian Colwell
- School of Public Health, Texas A&M University
- Michael Boivin
- Department of Psychiatry and Neurology & Ophthalmology, Michigan State University
- J. P. Banae Mayambu
- Ministry of Health National Program on Nutrition (PRONANUT)
- Daniel Okitundu
- Centre Neuro-Psychopathologique (CNPP), University of Kinshasa
- Arnaud Droit
- Computational Biology Laboratory, CHU de Québec - Université Laval Research Center
- Dieudonné Mumba Ngoyi
- Institut National de Recherche Biomédicale (INRB)
- Ran Blekhman
- Departments of Genetics, Cell Biology, and Development, University of Minnesota
- Desire Tshala-Katumbay
- Institut National de Recherche Biomédicale (INRB)
- Eric Vilain
- Center for Genetic Medicine Research, Children’s Research Institute, Children’s National Hospital
- DOI
- https://doi.org/10.1038/s41467-021-25694-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Here, using metagenomic profiling in 180 individuals from the Democratic Republic of the Congo, the authors find associations between the gut microbiome and konzo, a neurodegenerative disease that mostly affects children and is caused by the consumption improperly processed cassava.
