Nature Communications (Oct 2016)
Genomic heterogeneity of multiple synchronous lung cancer
- Yu Liu,
- Jianjun Zhang,
- Lin Li,
- Guangliang Yin,
- Jianhua Zhang,
- Shan Zheng,
- Hannah Cheung,
- Ning Wu,
- Ning Lu,
- Xizeng Mao,
- Longhai Yang,
- Jiexin Zhang,
- Li Zhang,
- Sahil Seth,
- Huang Chen,
- Xingzhi Song,
- Kan Liu,
- Yongqiang Xie,
- Lina Zhou,
- Chuanduo Zhao,
- Naijun Han,
- Wenting Chen,
- Susu Zhang,
- Longyun Chen,
- Wenjun Cai,
- Lin Li,
- Miaozhong Shen,
- Ningzhi Xu,
- Shujun Cheng,
- Huanming Yang,
- J. Jack Lee,
- Arlene Correa,
- Junya Fujimoto,
- Carmen Behrens,
- Chi-Wan Chow,
- William N. William,
- John V. Heymach,
- Waun Ki Hong,
- Stephen Swisher,
- Ignacio I. Wistuba,
- Jun Wang,
- Dongmei Lin,
- Xiangyang Liu,
- P. Andrew Futreal,
- Yanning Gao
Affiliations
- Yu Liu
- Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Jianjun Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Lin Li
- Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Guangliang Yin
- Beijing Genomics Institute
- Jianhua Zhang
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Shan Zheng
- Department of Pathology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Hannah Cheung
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Ning Wu
- Department of Diagnostic Imaging, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Ning Lu
- Department of Pathology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Xizeng Mao
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Longhai Yang
- Department of Thoracic Surgical Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Jiexin Zhang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Li Zhang
- Department of Diagnostic Imaging, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Sahil Seth
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Huang Chen
- Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Xingzhi Song
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Kan Liu
- Department of Diagnostic Imaging, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Yongqiang Xie
- Department of Pathology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Lina Zhou
- Department of Diagnostic Imaging, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Chuanduo Zhao
- Department of Thoracic Surgical Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Naijun Han
- Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Wenting Chen
- Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Susu Zhang
- Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Longyun Chen
- Beijing Genomics Institute
- Wenjun Cai
- Beijing Genomics Institute
- Lin Li
- Beijing Genomics Institute
- Miaozhong Shen
- Beijing Genomics Institute
- Ningzhi Xu
- Department of Cellular and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Shujun Cheng
- Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Huanming Yang
- Beijing Genomics Institute
- J. Jack Lee
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Arlene Correa
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Junya Fujimoto
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Carmen Behrens
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Chi-Wan Chow
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- William N. William
- Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- John V. Heymach
- Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Waun Ki Hong
- Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Stephen Swisher
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Ignacio I. Wistuba
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Jun Wang
- Beijing Genomics Institute
- Dongmei Lin
- Department of Pathology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- Xiangyang Liu
- Department of Thoracic Surgical Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- P. Andrew Futreal
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Yanning Gao
- Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
- DOI
- https://doi.org/10.1038/ncomms13200
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 8
Abstract
Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours.
