PP 8.1 – 00003 Optimization of the 5′ cap and untranslated regions enhances the immunogenicity of an mRNA-based therapeutic vaccine in SIV-infected rhesus macaques on ART

• W. Omange,
• B. Varco-Merth,
• A. Morenco,
• M.T. Chaunzwa,
• C. Nkoy,
• D. Duell,
• O. Fadeyi,
• M. Medina,
• S. Hoffmeister,
• W. Goodwin,
• R. Butler,
• Z. Etaki,
• H. Park,
• J. Smedley,
• M.K. Axhelm,
• S. Hansen,
• J. Lifson,
• J. Gergen,
• S. Rauch,
• B. Petsch,
• L.J. Picker,
• A.A. Okoye

Affiliations

W. Omange

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA

B. Varco-Merth

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

A. Morenco

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

M.T. Chaunzwa

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

C. Nkoy

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

D. Duell

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

O. Fadeyi

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

M. Medina

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

S. Hoffmeister

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

W. Goodwin

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

R. Butler

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

Z. Etaki

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

H. Park

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

J. Smedley

Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

M.K. Axhelm

Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

S. Hansen

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

J. Lifson

AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

J. Gergen

CureVac AG, Tübingen, Germany

S. Rauch

CureVac AG, Tübingen, Germany

B. Petsch

CureVac AG, Tübingen, Germany

L.J. Picker

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

A.A. Okoye

Vaccine and Gene therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA