ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY

Abstract

This article is focused on the pathophysiology, prevalence , clinical manifestations, diagnosis, and treatment C deficiency with increased risk of thrombosis. Activated protein C (aPC) exerts its anticoagulant activity through inactivation of coagulation factors Va and VIIIa. Aside its anticoagulant property, aPC demonstrates anti-inflammatory and cytoprotectiveeffects, which are mediated through the endothelial protein C receptor and the protease-activated receptor-I (PAR-1). Studying and understanding the biological function of APS makes it possible to control coagulation and inflammation and to apply protein C preparations as anticoagulant and cytoprotective drugs in a physicians clinicalpractice.

Keywords

• activated protein c
• aps resistance
• factor v leiden mutation
• thromboses
• endothelial protein c receptor