CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model

Noah R. Johnson; Peng Yuan; Erika Castillo; T. Peter Lopez; Weizhou Yue; Annalise Bond; Brianna M. Rivera; Miranda C. Sullivan; Masakazu Hirouchi; Kurt Giles; Atsushi Aoyagi; Carlo Condello

doi:10.1038/s41467-022-35753-w

Nature Communications (Jan 2023)

CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model

Noah R. Johnson,
Peng Yuan,
Erika Castillo,
T. Peter Lopez,
Weizhou Yue,
Annalise Bond,
Brianna M. Rivera,
Miranda C. Sullivan,
Masakazu Hirouchi,
Kurt Giles,
Atsushi Aoyagi,
Carlo Condello

Affiliations

Noah R. Johnson: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Peng Yuan: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Erika Castillo: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
T. Peter Lopez: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Weizhou Yue: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Annalise Bond: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Brianna M. Rivera: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Miranda C. Sullivan: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Masakazu Hirouchi: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Kurt Giles: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Atsushi Aoyagi: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California
Carlo Condello: Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California

DOI: https://doi.org/10.1038/s41467-022-35753-w
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 23

Abstract

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Tau-mediated neurodegeneration is driven by disease-activated microglia and suppressed by their pharmacological blockade. The authors identified drug dose- and sex-dependent residual microglial phenotypes, neuronal excitotoxicity, and animal survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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