Nature Communications (Jul 2020)

Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191

  • Pooja Sanduja,
  • Manish Gupta,
  • Vikas Kumar Somani,
  • Vikas Yadav,
  • Meenakshi Dua,
  • Emanuel Hanski,
  • Abhinay Sharma,
  • Rakesh Bhatnagar,
  • Atul Kumar Johri

DOI
https://doi.org/10.1038/s41467-020-17299-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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A high number of serotypes makes vaccine development to group A Streptococcus (GAS) difficult. Here, the authors use a reverse vaccinology approach and identify SPy_2191 as conserved surface protein that inhibits GAS adhesion and invasion and induces cross-protective immunity in mice.