Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent

Shanti Marasini; Huan Yue; Adibehalsadat Ghazanfari; Son Long Ho; Ji Ae Park; Soyeon Kim; Hyunsil Cha; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Abdullah Khamis Ali Al Saidi; Dejun Zhao; Ying Liu; Kwon-Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.3390/app11178222

Applied Sciences (Sep 2021)

Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent

Shanti Marasini,
Huan Yue,
Adibehalsadat Ghazanfari,
Son Long Ho,
Ji Ae Park,
Soyeon Kim,
Hyunsil Cha,
Shuwen Liu,
Tirusew Tegafaw,
Mohammad Yaseen Ahmad,
Abdullah Khamis Ali Al Saidi,
Dejun Zhao,
Ying Liu,
Kwon-Seok Chae,
Yongmin Chang,
Gang Ho Lee

Affiliations

Shanti Marasini: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Huan Yue: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Adibehalsadat Ghazanfari: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Son Long Ho: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Ji Ae Park: Division of RI-Convergence Research, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01817, Korea
Soyeon Kim: Division of RI-Convergence Research, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01817, Korea
Hyunsil Cha: Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Korea
Shuwen Liu: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Tirusew Tegafaw: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Mohammad Yaseen Ahmad: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Abdullah Khamis Ali Al Saidi: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Dejun Zhao: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Ying Liu: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Kwon-Seok Chae: Department of Biology Education, Teachers’ College, Kyungpook National University, Taegu 41566, Korea
Yongmin Chang: Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Korea
Gang Ho Lee: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea

DOI: https://doi.org/10.3390/app11178222
Journal volume & issue: Vol. 11, no. 17
p. 8222

Abstract

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Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2/r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

Published in Applied Sciences

ISSN: 2076-3417 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General); Science: Biology (General); Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/applsci

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