Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives

Jinming Yang; Qiang Li; Juanjuan Zhang; Wei Lin; Juxian Wang; Yucheng Wang; Zhibin Huang; Daqing Shi

doi:10.3390/molecules181214519

Molecules (Nov 2013)

Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives

Jinming Yang,
Qiang Li,
Juanjuan Zhang,
Wei Lin,
Juxian Wang,
Yucheng Wang,
Zhibin Huang,
Daqing Shi

Affiliations

Jinming Yang: School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu, China
Qiang Li: Hainan Chuntch Pharmaceutical Company Limited, Haikou 570216, Hainan, China
Juanjuan Zhang: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China
Wei Lin: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China
Juxian Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Perkin Union, Medical College, Beijing 100050, China
Yucheng Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Perkin Union, Medical College, Beijing 100050, China
Zhibin Huang: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China
Daqing Shi: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China

DOI: https://doi.org/10.3390/molecules181214519
Journal volume & issue: Vol. 18, no. 12
pp. 14519 – 14528

Abstract

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An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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