Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives
Jinming Yang,
Qiang Li,
Juanjuan Zhang,
Wei Lin,
Juxian Wang,
Yucheng Wang,
Zhibin Huang,
Daqing Shi
Affiliations
Jinming Yang
School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu, China
Qiang Li
Hainan Chuntch Pharmaceutical Company Limited, Haikou 570216, Hainan, China
Juanjuan Zhang
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China
Wei Lin
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China
Juxian Wang
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Perkin Union, Medical College, Beijing 100050, China
Yucheng Wang
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Perkin Union, Medical College, Beijing 100050, China
Zhibin Huang
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China
Daqing Shi
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China
An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.
