PLoS ONE (Jan 2014)

Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men.

  • Sofie H Mooij,
  • Hein J Boot,
  • Arjen G C L Speksnijder,
  • Chris J L M Meijer,
  • Audrey J King,
  • Dominique W M Verhagen,
  • Henry J C de Vries,
  • Wim G V Quint,
  • Anco Molijn,
  • Maurits N C de Koning,
  • Marianne A B van der Sande,
  • Maarten F Schim van der Loeff

DOI
https://doi.org/10.1371/journal.pone.0098955
Journal volume & issue
Vol. 9, no. 6
p. e98955

Abstract

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ObjectivesOur aim was to assess incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).MethodsMSM aged ≥18 years were included in Amsterdam (the Netherlands) in 2010-2011, and followed up 6 months later. Participants completed risk factor questionnaires. HPV DNA was analyzed in oral-rinse and gargle specimens using the SPF10-PCR DEIA/LiPA25 system (version 1). A subset of oral samples was subjected to SPF10 sequencing to identify additional HPV types. Multivariable logistic regression analyses using generalized estimating equations (GEE) were performed to assess determinants for oral high-risk HPV incidence and persistence.Results689/795 participant MSM provided both baseline and 6-month data. Baseline prevalence of high-risk HPV was 9.4% in HIV-negative and 23.9% in HIV-infected MSM (PConclusionIncidence of oral high-risk HPV infection in MSM is substantial, and is associated with HIV infection. Over a third of HPV infections persisted over a 6-month period.