Nature Communications (Apr 2016)
The molecular basis of the genesis of basal tone in internal anal sphincter
- Cheng-Hai Zhang,
- Pei Wang,
- Dong-Hai Liu,
- Cai-Ping Chen,
- Wei Zhao,
- Xin Chen,
- Chen Chen,
- Wei-Qi He,
- Yan-Ning Qiao,
- Tao Tao,
- Jie Sun,
- Ya-Jing Peng,
- Ping Lu,
- Kaizhi Zheng,
- Siobhan M. Craige,
- Lawrence M. Lifshitz,
- John F. Keaney Jr,
- Kevin E. Fogarty,
- Ronghua ZhuGe,
- Min-Sheng Zhu
Affiliations
- Cheng-Hai Zhang
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Pei Wang
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Dong-Hai Liu
- Department of Microbiology and Physiological Systems, University of Massachusetts Medical School
- Cai-Ping Chen
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Wei Zhao
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Xin Chen
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Chen Chen
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Wei-Qi He
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Yan-Ning Qiao
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Tao Tao
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Jie Sun
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Ya-Jing Peng
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- Ping Lu
- Department of Microbiology and Physiological Systems, University of Massachusetts Medical School
- Kaizhi Zheng
- Department of Microbiology and Physiological Systems, University of Massachusetts Medical School
- Siobhan M. Craige
- Department of Medicine, University of Massachusetts Medical School
- Lawrence M. Lifshitz
- Program in Molecular Medicine, University of Massachusetts Medical School
- John F. Keaney Jr
- Department of Medicine, University of Massachusetts Medical School
- Kevin E. Fogarty
- Program in Molecular Medicine, University of Massachusetts Medical School
- Ronghua ZhuGe
- Department of Microbiology and Physiological Systems, University of Massachusetts Medical School
- Min-Sheng Zhu
- State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
- DOI
- https://doi.org/10.1038/ncomms11358
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2+channel-MLC kinase pathway, suggesting a potential therapy for IAS motility disorders.
