Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice

Lixiang Wang; Xin Li; Yuki Hanada; Nao Hasuzawa; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto

doi:10.1038/s42003-021-02413-6

Communications Biology (Jul 2021)

Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice

Lixiang Wang,
Xin Li,
Yuki Hanada,
Nao Hasuzawa,
Yoshinori Moriyama,
Masatoshi Nomura,
Ken Yamamoto

Affiliations

Lixiang Wang: Department of Medical Biochemistry, Kurume University School of Medicine
Xin Li: Department of Molecular Pathobiology, New York University College of Dentistry
Yuki Hanada: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
Nao Hasuzawa: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine
Yoshinori Moriyama: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine
Masatoshi Nomura: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
Ken Yamamoto: Department of Medical Biochemistry, Kurume University School of Medicine

DOI: https://doi.org/10.1038/s42003-021-02413-6
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Wang et al. report that deficiency of dynamin-related protein 1, which controls mitochondrial fission, accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice. Thus, they highlight mitochondria dynamics dysfunction as a new mechanism of liver disease development.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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