Bone protection by inhibition of microRNA-182

Kazuki Inoue; Zhonghao Deng; Yufan Chen; Eugenia Giannopoulou; Ren Xu; Shiaoching Gong; Matthew B. Greenblatt; Lingegowda S. Mangala; Gabriel Lopez-Berestein; David G. Kirsch; Anil K. Sood; Liang Zhao; Baohong Zhao

doi:10.1038/s41467-018-06446-0

Nature Communications (Oct 2018)

Bone protection by inhibition of microRNA-182

Kazuki Inoue,
Zhonghao Deng,
Yufan Chen,
Eugenia Giannopoulou,
Ren Xu,
Shiaoching Gong,
Matthew B. Greenblatt,
Lingegowda S. Mangala,
Gabriel Lopez-Berestein,
David G. Kirsch,
Anil K. Sood,
Liang Zhao,
Baohong Zhao

Affiliations

Kazuki Inoue: Arthritis and Tissue Degeneration Program, The David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
Zhonghao Deng: Arthritis and Tissue Degeneration Program, The David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
Yufan Chen: Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University
Eugenia Giannopoulou: Arthritis and Tissue Degeneration Program, The David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
Ren Xu: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College
Shiaoching Gong: Department of Molecular Biology, The Rockefeller University
Matthew B. Greenblatt: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College
Lingegowda S. Mangala: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Gabriel Lopez-Berestein: Center for RNA Interference and Noncoding RNA, The University of Texas MD Anderson Cancer Center
David G. Kirsch: Department of Radiation Oncology and Department of Pharmacology and Cancer Biology, Duke University Medical Center
Anil K. Sood: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Liang Zhao: Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University
Baohong Zhao: Arthritis and Tissue Degeneration Program, The David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery

DOI: https://doi.org/10.1038/s41467-018-06446-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Osteoclasts mediate bone disruption in a number of degenerative bone diseases. Here, the authors show that miR-182 regulates osteoclastogenesis via PKR and IFN-beta signaling, is correlated with rheumatoid arthritis, and that its ablation or inhibition is protective against bone erosion in mouse models of osteoporosis or inflammatory arthritis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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