Emerging Infectious Diseases (Jan 2010)

Acute Encephalopathy Associated with Influenza A Infection in Adults

  • Nelson Lee,
  • Chun Kwok Wong,
  • Paul K.S. Chan,
  • Niklas Lindegardh,
  • Nicholas J. White,
  • Frederick G. Hayden,
  • Edward H.C. Wong,
  • Ka Shing Wong,
  • Clive S. Cockram,
  • Joseph J.Y. Sung,
  • David S.C. Hui

DOI
https://doi.org/10.3201/eid1601.090077
Journal volume & issue
Vol. 16, no. 1
pp. 139 – 142

Abstract

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We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios >3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.

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