Immunohistochemical Analysis of Placental Microvessel Density and Spiral Artery Doppler Results in Preeclamptic Pregnancies

Abstract

INTRODUCTION[|]To investigate placental immunohistochemical findings and Doppler parameters in normal pregnancies and women with preeclampsia (PE).[¤]METHODS[|]Doppler measurements of umbilical, uterine, and spiral arteries of 23 PE and 12 normal pregnancies followed and delivered between 2008 and 2010 were performed and recorded. Placental specimens were obtained at birth and the microvessel density of spiral arteries was measured immunohistochemically using placental tissue CD 34 antibody expression. Three vessels with the most intense CD34 density were evaluated.[¤]RESULTS[|]There were no significant differences in the umbilical artery pulsatility index (PI), resistance index (RI), or systolic/diastolic ratio (S/D) between the PE and normal pregnancies. The spiral and uterine artery RI, PI, and SD ratios, however, were significantly higher in the PE group. There was no statistically significant difference in the mean microvessel density between the 2 groups.[¤]DISCUSSION AND CONCLUSION[|]The role of the placenta in the development of PE is unquestionable. Vascular pathologies and blood flow characteristics demonstrate significant differences and deteriorations compared with normal pregnancies. Further research is needed to further define the precise pathology.[¤]

Keywords

• antijenler cd34
• mikrodamarlar
• pre-eklampsi
• ultrasonografi doppler.