The role of the small intestine in the development of metabolic syndrome

Abstract

AIM: To comprehensively investigate the function of the small intestine (SI) in metabolic syndrome (MS). /MATERIAL AND METHODS: Seventy-eight patients with MS were examined using, in addition to clinical studies, comprehensive ones of the function of SI: evaluation of its motor, digestive, and absorptive functions. The specific features of the hormonal and autonomic status were studied in the patients with MS /RESULTS: Clinical local and common signs of SI lesion were seen in 82.9% of the patients. Examination of SI function revealed its impairments at all stages of hydrolysis and resorption in the presence of hypomotor dyskinesia in the postprandial period and hypersympaticotonia in the patients with MS. New pathogenic patterns were found in relation to the role of hormones in intestinal digestive and absorptive dysfunctions in MS /CONCLUSION: The findings may suggest that SI functional changes found in MS are an important component of its complex pathogenetic circle.

Keywords

• metabolic syndrome
• small intestinal function
• hormones
• autonomic status