Nature Communications (Aug 2021)
Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors
- Katie L. Kunze,
- Patrick W. Johnson,
- Noud van Helmond,
- Jonathon W. Senefeld,
- Molly M. Petersen,
- Stephen A. Klassen,
- Chad C. Wiggins,
- Allan M. Klompas,
- Katelyn A. Bruno,
- John R. Mills,
- Elitza S. Theel,
- Matthew R. Buras,
- Michael A. Golafshar,
- Matthew A. Sexton,
- Juan C. Diaz Soto,
- Sarah E. Baker,
- John R. A. Shepherd,
- Nicole C. Verdun,
- Peter Marks,
- Nigel S. Paneth,
- DeLisa Fairweather,
- R. Scott Wright,
- Camille M. van Buskirk,
- Jeffrey L. Winters,
- James R. Stubbs,
- Katherine A. Senese,
- Michaela C. Pletsch,
- Zachary A. Buchholtz,
- Robert F. Rea,
- Vitaly Herasevich,
- Emily R. Whelan,
- Andrew J. Clayburn,
- Kathryn F. Larson,
- Juan G. Ripoll,
- Kylie J. Andersen,
- Elizabeth R. Lesser,
- Matthew N. P. Vogt,
- Joshua J. Dennis,
- Riley J. Regimbal,
- Philippe R. Bauer,
- Janis E. Blair,
- Arturo Casadevall,
- Rickey E. Carter,
- Michael J. Joyner
Affiliations
- Katie L. Kunze
- Department of Quantitative Health Sciences, Mayo Clinic
- Patrick W. Johnson
- Department of Quantitative Health Sciences, Mayo Clinic
- Noud van Helmond
- Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care
- Jonathon W. Senefeld
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Molly M. Petersen
- Department of Quantitative Health Sciences, Mayo Clinic
- Stephen A. Klassen
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Chad C. Wiggins
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Allan M. Klompas
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Katelyn A. Bruno
- Department of Cardiovascular Medicine, Mayo Clinic
- John R. Mills
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Elitza S. Theel
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Matthew R. Buras
- Department of Quantitative Health Sciences, Mayo Clinic
- Michael A. Golafshar
- Department of Quantitative Health Sciences, Mayo Clinic
- Matthew A. Sexton
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Juan C. Diaz Soto
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Sarah E. Baker
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- John R. A. Shepherd
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Nicole C. Verdun
- Center for Biologics Evaluation and Research, U.S. Food and Drug Administration
- Peter Marks
- Center for Biologics Evaluation and Research, U.S. Food and Drug Administration
- Nigel S. Paneth
- Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University
- DeLisa Fairweather
- Department of Cardiovascular Medicine, Mayo Clinic
- R. Scott Wright
- Department of Cardiovascular Medicine, Mayo Clinic
- Camille M. van Buskirk
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Jeffrey L. Winters
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- James R. Stubbs
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Katherine A. Senese
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Michaela C. Pletsch
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Zachary A. Buchholtz
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Robert F. Rea
- Department of Cardiovascular Medicine, Mayo Clinic
- Vitaly Herasevich
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Emily R. Whelan
- Department of Cardiovascular Medicine, Mayo Clinic
- Andrew J. Clayburn
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Kathryn F. Larson
- Department of Cardiovascular Medicine, Mayo Clinic
- Juan G. Ripoll
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Kylie J. Andersen
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Elizabeth R. Lesser
- Department of Quantitative Health Sciences, Mayo Clinic
- Matthew N. P. Vogt
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Joshua J. Dennis
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Riley J. Regimbal
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- Philippe R. Bauer
- Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic
- Janis E. Blair
- Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic
- Arturo Casadevall
- Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health
- Rickey E. Carter
- Department of Quantitative Health Sciences, Mayo Clinic
- Michael J. Joyner
- Department of Anesthesiology and Perioperative Medicine, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-021-25113-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 6
Abstract
Regional differences in SARS-CoV-2 variants may affect treatment outcome. Here, the authors show that near-sourced convalescent plasma has higher efficacy, as defined by death within 30 days of transfusion, than plasma sourced more than 150 miles away.
