Different Factors Influencing Early Stages of Intestine Microbiota Formation

Abstract

Thanks to modern molecular-genetic microbiota analysis, numerous previously unstudied bacteria were identified. As a result, the conception of human microbiocenosis was significally changed, particularly the conception of intestinal microbiota, which substantially determines human health. The ways the bacteria affect the metagenome, endocrine regulation and function of the nervous system have been described in recent years. At its early stages, the formation of intestinal microbiota depends on such factors as a complicated gestation course, prematurity, surgical delivery, late breast latching, artificial feeding since birth or antibiotic therapy. However, the results of latest studies indicate that the microbial factor affects children long before their birth. Present scientific hypothesis regarding torpid microbial inflammation in uterine cavity as a cause of disturbanses in the gestation course or of preterm labour was also formed in connection with investigating placenta and amniotic fluid microbiocenoses. This survey presents analysis of the latest data concerning the affection of both antenatal and postnatal factors at early stages of intestinal microbiota conditioning in children.

Keywords

• intestinal microbiocenosis
• microbiota
• probiotics
• prebiotics
• perinatal pathology