Advances in Respiratory Medicine (Jun 2023)

Single Nucleotide Polymorphisms of <i>FAM13A</i> Gene in Chronic Obstructive Pulmonary Disease—A Case Control Study in Vietnam

  • Khanh Hoang Pham,
  • Nhung Thi Cam Tran,
  • Hung Do Tran,
  • Toan Hoang Ngo,
  • Van De Tran,
  • Hung Huynh Vinh Ly,
  • Nga Thi Ngoc Pham,
  • Thang Nguyen,
  • Binh Huy Nguyen,
  • Kien Trung Nguyen

DOI
https://doi.org/10.3390/arm91030021
Journal volume & issue
Vol. 91, no. 3
pp. 268 – 277

Abstract

Read online

Background: In 2018, GOLD addressed the issues of genotypes associated with risk factors for COPD. The genome-wide association study (GWAS) demonstrated an association between COPD and several genetic variants of single nucleotide polymorphisms (SNPs) of the FAM13A gene with the risk of COPD. Objective: To study the single nucleotide polymorphisms rs2869967 and rs17014601 of the FAM13A gene in chronic obstructive pulmonary disease. Subjects and research methods: 80 subjects diagnosed with COPD and 80 subjects determined not to have COPD according to GOLD 2020 criteria; the subjects were clinically examined, interviewed, and identified as possessing single nucleotide polymorphisms using the sanger sequencing method on whole blood samples. Results: The male/female ratio of the patient group and the control group was 79/1 and 39/1, respectively. The percentages of C and T alleles of rs2869967 in COPD patients were 50.6% and 49.4%, respectively. The percentages of C and T alleles of rs17014601 in COPD patients were 31.9% and 68.1%, respectively. At rs17014601, the ratio values of alleles T and C in the disease group and the control group were markedly different, making them statistically reliable (p = 0.031). The rate of CT genotype in the group of patients was considerably higher than that of the control group. The TT homozygous genotype had a lower risk of COPD compared with the other genotypes in the dominant model (ORTT/(CC + CT) = 0.441; CI95% = 0.233–0.833); this difference was statistically significant (p = 0.012). Conclusions: With rs17014601, it is characteristic that the frequency of the T allele appears more than the C allele, and the CT heterozygous phenotype accounts for the highest proportion in rs17014601 and rs2869967 recorded in COPD patients. There is an association between the genetic variant of the SNP FAM13A-rs17014601 and the risk of COPD.

Keywords