Marine Drugs (Dec 2014)

Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021

  • Qifeng Yao,
  • Jie Wang,
  • Xiaoyong Zhang,
  • Xuhua Nong,
  • Xinya Xu,
  • Shuhua Qi

DOI
https://doi.org/10.3390/md12125902
Journal volume & issue
Vol. 12, no. 12
pp. 5902 – 5915

Abstract

Read online

Eight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC50 values of 4.9 and 8.8 μM, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement.

Keywords