Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity

Japheth O. Ombito; Gomotsang Bojase; Runner R.T. Majinda; Ishmael B. Masesane; Anja Schüffler; Till Opatz

Arabian Journal of Chemistry (Feb 2020)

Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity

Japheth O. Ombito,
Gomotsang Bojase,
Runner R.T. Majinda,
Ishmael B. Masesane,
Anja Schüffler,
Till Opatz

Affiliations

Japheth O. Ombito: Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana; Corresponding author.
Gomotsang Bojase: Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana
Runner R.T. Majinda: Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana
Ishmael B. Masesane: Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana
Anja Schüffler: Institut für Biotechnologie und Wirkstoff-Forschung gGmbH, Erwin-Schrödinger-Straße 56, D-67663 Kaiserslautern, Germany
Till Opatz: Johannes Gutenberg University Mainz, Institute of Organic Chemistry, Duesbergweg 10–14, D-55128 Mainz, Germany

Journal volume & issue: Vol. 13, no. 2
pp. 4019 – 4023

Abstract

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Two previously undescribed isoflavones, erysacleuxin C (1) and erysacleuxin D (2), together with seven known compounds (3–9), were isolated and identified from the EtOAc extract of the twigs of Erythrina sacleuxii Hua (Leguminosae). The structures of the isolated compounds were determined on the basis of their spectroscopic and spectrometric data. Evaluation of their cytotoxicity against the human cancer HeLa-S3 cell lines indicated IC50 values of 130.4, 54.9 and 73.9 µM for erysacleuxin C (1), erysacleuxin D (2) and butin (9), respectively. Keywords: Erythrina sacleuxii, Leguminosae, Isoflavone, Erysacleuxin C, Erysacleuxin D, Cytotoxicity

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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