Communications Biology (Jul 2022)

PI3Kδ activity controls plasticity and discriminates between EMT and stemness based on distinct TGFβ signaling

  • Jean Agnetti,
  • Vanessa Bou Malham,
  • Christophe Desterke,
  • Nassima Benzoubir,
  • Juan Peng,
  • Sophie Jacques,
  • Souad Rahmouni,
  • Emanuel Di Valentin,
  • Tuan Zea Tan,
  • Didier Samuel,
  • Jean Paul Thiery,
  • Ama Gassama-Diagne

DOI
https://doi.org/10.1038/s42003-022-03637-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 15

Abstract

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Overexpression of isoform δ of phosphoinositide 3-kinase (PI3Kδ) promotes stemness in hepatocellular carcinoma cell lines and mouse liver, whereas its inhibition promotes EMT, suggesting a key role for PI3Kδ in epithelial plasticity.