BMC Genomics
(Feb 2022)
Natterin-like depletion by CRISPR/Cas9 impairs zebrafish (Danio rerio) embryonic development
Ana Carolina Seni-Silva,
Adolfo Luis Almeida Maleski,
Milena Marcolino Souza,
Maria Alice Pimentel Falcao,
Geonildo Rodrigo Disner,
Monica Lopes-Ferreira,
Carla Lima
Affiliations
Ana Carolina Seni-Silva
Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute
Adolfo Luis Almeida Maleski
Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute
Milena Marcolino Souza
Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute
Maria Alice Pimentel Falcao
Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute
Geonildo Rodrigo Disner
Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute
Monica Lopes-Ferreira
Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute
Carla Lima
Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute
DOI
https://doi.org/10.1186/s12864-022-08369-z
Journal volume & issue
Vol. 23,
no. 1
Abstract
Read online
Highlights The Natterin family was discovered in the venom of the fish Thalassophryne nattereri. The zebrafish genome encodes eleven natterin-like genes. Natterin-like might be a novel fish-specific defense molecule. Natterin-like proteins are thought to be pore-forming molecules. Reverse genetic study and phenotypic characterization suggests natterin-like genes may have roles in zebrafish development.
Keywords
WeChat QR code
Close
