Mechanistic characterization of titanium dioxide nanoparticle-induced toxicity using electron spin resonance

Journal of Food and Drug Analysis. 2014;22(1):76-85 DOI 10.1016/j.jfda.2014.01.006

 

Journal Homepage

Journal Title: Journal of Food and Drug Analysis

ISSN: 1021-9498 (Print)

Publisher: Elsevier

Society/Institution: Food and Drug Administration of Taiwan

LCC Subject Category: Technology: Home economics: Nutrition. Foods and food supply | Medicine: Therapeutics. Pharmacology

Country of publisher: Taiwan, Province of China

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Meng Li (Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA)
Jun-Jie Yin (Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA)
Wayne G. Wamer (Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA)
Y. Martin Lo (Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 6 weeks

 

Abstract | Full Text

Titanium dioxide nanoparticles (TiO2 NPs) are one of the most widely used nanomaterials that have been manufactured worldwide and applied in different commercial realms. The well-recognized ability of TiO2 to promote the formation of reactive oxygen species (ROS) has been extensively studied as one of the important mechanisms underlying TiO2 NPs toxicity. As the “gold standard” method to quantify and identify ROS, electron spin resonance (ESR) spectroscopy has been employed in many studies aimed at evaluating TiO2 NPs safety. This review aims to provide a thorough discussion of current studies using ESR as the primary method to unravel the mechanism of TiO2 NPs toxicity. ESR spin label oximetry and immune-spin trapping techniques are also briefly introduced, because the combination of spin trapping/labeling techniques offers a promising tool for studying the oxidative damage caused by TiO2 NPs.