EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS

Abstract

Objective. To study the effect of the protective agent ethylmethylhydroxypyridine malate on the numbers of erythroblastic islets in rats exposed to sulfur-containing gases. Materials and methods. Natural sulfur-containing gas mixtures from the Astrakhan gas-condensate field were used to model the gas-polluted environment. Male rats of various ages simulated different stages of postnatal human ontogenesis. Results. The obtained results indicate that at all stages of ontogenesis ethylmethylhydroxypyridine malate protected erythroblastic islets from intoxication by gaseous sulfur pollutants and led to partial normalization of proliferation and maturation of eryth rob lasts. Conclusion. The protective action of ethylmethylhydroxypyridine malate may be used for neutralizing the biological damage caused by toxic air pollutants at different stages of ontogenesis.

Keywords

• erythropoiesis
• sulfur dioxide
• ethylmethylhydroxypyridine malate
• rats
• stages of ontogeny