The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Julie Rayes; Siân Lax; Surasak Wichaiyo; Stephanie K. Watson; Ying Di; Stephanie Lombard; Beata Grygielska; Stuart W. Smith; Kassiani Skordilis; Steve P. Watson

doi:10.1038/s41467-017-02402-6

Nature Communications (Dec 2017)

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Julie Rayes,
Siân Lax,
Surasak Wichaiyo,
Stephanie K. Watson,
Ying Di,
Stephanie Lombard,
Beata Grygielska,
Stuart W. Smith,
Kassiani Skordilis,
Steve P. Watson

Affiliations

Julie Rayes: Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham
Siân Lax: Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham
Surasak Wichaiyo: Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham
Stephanie K. Watson: Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham
Ying Di: Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham
Stephanie Lombard: Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham
Beata Grygielska: Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham
Stuart W. Smith: Department of Renal Medicine, New Queen Elizabeth, Hospital Birmingham
Kassiani Skordilis: Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham
Steve P. Watson: Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham

DOI: https://doi.org/10.1038/s41467-017-02402-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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