MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis

Abstract

Matsuzawa et al. show that adhesion-related molecules MAGI-1 and MAGI-3 localize partitioning defective-3 (Par-3) at apical junctional complexes of cells throughout the epithelial monolayer. This study provides insights into how tension distribution contributes to cellular contractility in epithelial tissue homeostasis.