Memorias do Instituto Oswaldo Cruz (Jul 2018)

Genome sequence of a multidrug-resistant Corynebacterium striatum isolated from bloodstream infection from a nosocomial outbreak in Rio de Janeiro, Brazil

  • Juliana Nunes Ramos,
  • Izabel dos Santos Rodrigues,
  • Paulo Victor Pereira Baio,
  • João Flávio Carneiro Veras,
  • Rommel Thiago Jucá Ramos,
  • Luis GC Pacheco,
  • Vasco Ariston Azevedo,
  • Raphael Hirata Júnior,
  • Michel Abanto Marín,
  • Ana Luiza de Mattos-Guaraldi,
  • Verônica Viana Vieira

DOI
https://doi.org/10.1590/0074-02760180051
Journal volume & issue
Vol. 113, no. 9

Abstract

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Multidrug-resistant (MDR) Corynebacterium striatum has been cited with increased frequency as pathogen of nosocomial infections. In this study, we report the draft genome of a C. striatum isolated from a patient with bloodstream infection in a hospital of Rio de Janeiro, Brazil. The isolate presented susceptibility only to tetracycline, vancomycin and linezolid. The detection of various antibiotic resistance genes is fully consistent with previously observed multidrug-resistant pattern in Corynebacterium spp. A large part of the pTP10 plasmid of MDR C. striatum M82B is present in the genome of our isolate. A SpaDEF cluster and seven arrays of CRISPR-Cas were found.

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