Nature Communications (Mar 2016)
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
- Xiujuan Li,
- Narendra Padhan,
- Elisabet O. Sjöström,
- Francis P. Roche,
- Chiara Testini,
- Naoki Honkura,
- Miguel Sáinz-Jaspeado,
- Emma Gordon,
- Katie Bentley,
- Andrew Philippides,
- Vladimir Tolmachev,
- Elisabetta Dejana,
- Radu V. Stan,
- Dietmar Vestweber,
- Kurt Ballmer-Hofer,
- Christer Betsholtz,
- Kristian Pietras,
- Leif Jansson,
- Lena Claesson-Welsh
Affiliations
- Xiujuan Li
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Narendra Padhan
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Elisabet O. Sjöström
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Francis P. Roche
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Chiara Testini
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Naoki Honkura
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Miguel Sáinz-Jaspeado
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Emma Gordon
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Katie Bentley
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Andrew Philippides
- Centre for Computational Neuroscience and Robotics, University of Sussex
- Vladimir Tolmachev
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Elisabetta Dejana
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Radu V. Stan
- Department of Pathology, Dartmouth College, Geisel School of Medicine at Dartmouth
- Dietmar Vestweber
- Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine
- Kurt Ballmer-Hofer
- Biomolecular Research, Molecular Cell Biology, Paul-Scherrer Institute
- Christer Betsholtz
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- Kristian Pietras
- Translational Cancer Research, Medicon Village, Lund University
- Leif Jansson
- Department of Medical Cell Biology, Biomedical Center, Uppsala University
- Lena Claesson-Welsh
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University
- DOI
- https://doi.org/10.1038/ncomms11017
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without affecting tumor inflammation.
