HP0175 Promotes the Production of IL-23, IL-6, IL-1β and TGF-β

A. Amedei; F. Munari; C. Della Bella; E. Niccolai; M. Benagiano; L. Bencini; F. Cianchi; E. Silvestri; S. D'Elios; M. Farsi; D. Prisco; G. Zanotti; M. De Bernard; M. Kundu; M.M. D'Elios

doi:10.1177/1721727X1301100127

European Journal of Inflammation (Jan 2013)

HP0175 Promotes the Production of IL-23, IL-6, IL-1β and TGF-β

A. Amedei,
F. Munari,
C. Della Bella,
E. Niccolai,
M. Benagiano,
L. Bencini,
F. Cianchi,
E. Silvestri,
S. D'Elios,
M. Farsi,
D. Prisco,
G. Zanotti,
M. De Bernard,
M. Kundu,
M.M. D'Elios

Affiliations

A. Amedei: Department of Biomedicine, Institute of Medical Pathology, Florence, Italy
F. Munari: Venetian Institute of Molecular Medicine, university of Padua, Padua, Italy
C. Della Bella: Department of Biomedicine, Institute of Medical Pathology, Florence, Italy
E. Niccolai: Department of Biomedicine, Institute of Medical Pathology, Florence, Italy
M. Benagiano: Department of Biomedicine, Institute of Medical Pathology, Florence, Italy
L. Bencini: Department of General and Oncologic Surgery, University of Florence, Florence, Italy
F. Cianchi: Department of Surgery, University of Florence, Florence, Italy
E. Silvestri: Department of Biomedicine, Institute of Medical Pathology, Florence, Italy
S. D'Elios: Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
M. Farsi: Department of General and Oncologic Surgery, University of Florence, Florence, Italy
D. Prisco: Department of Biomedicine, Institute of Medical Pathology, Florence, Italy
G. Zanotti: Venetian Institute of Molecular Medicine, university of Padua, Padua, Italy
M. De Bernard: Venetian Institute of Molecular Medicine, university of Padua, Padua, Italy
M. Kundu: Department of Chemistry, Bose Institute, Kolkata, India
M.M. D'Elios: Department of Biomedicine, Institute of Medical Pathology, Florence, Italy

DOI: https://doi.org/10.1177/1721727X1301100127
Journal volume & issue: Vol. 11

Abstract

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Helicobacter pylori infection induces a chronic gastric inflammatory infiltrate. This study was undertaken to evaluate the type of the innate immune responses elicited by the secreted peptidyl-prolyl cis-trans isomerase of H. pylori (HP0175). The cytokine production induced by HP0175 in neutrophils, and monocytes was evaluated. HP0175 was able to induce the expression of IL-23 in neutrophils, and monocytes, and IL-6, IL-1beta and TGF-beta in monocytes. These findings indicate that HP0175 is able to promote the activation of innate cells and the production of a cytokine milieu that may favour the development of Th17 response.

Published in European Journal of Inflammation

ISSN: 1721-727X (Print); 2058-7392 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://journals.sagepub.com/home/eji

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