Nature Communications (Nov 2021)
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis
- Maxime Uriarte,
- Nadine Sen Nkwe,
- Roch Tremblay,
- Oumaima Ahmed,
- Clémence Messmer,
- Nazar Mashtalir,
- Haithem Barbour,
- Louis Masclef,
- Marion Voide,
- Claire Viallard,
- Salima Daou,
- Djaileb Abdelhadi,
- Daryl Ronato,
- Mohammadjavad Paydar,
- Anaïs Darracq,
- Karine Boulay,
- Nicolas Desjardins-Lecavalier,
- Przemyslaw Sapieha,
- Jean-Yves Masson,
- Mikhail Sergeev,
- Benjamin H. Kwok,
- Laura Hulea,
- Frédérick A. Mallette,
- Eric Milot,
- Bruno Larrivée,
- Hugo Wurtele,
- El Bachir Affar
Affiliations
- Maxime Uriarte
- Department of Biochemistry and Molecular Medicine, University of Montréal
- Nadine Sen Nkwe
- Maisonneuve-Rosemont Hospital Research Center
- Roch Tremblay
- Maisonneuve-Rosemont Hospital Research Center
- Oumaima Ahmed
- Maisonneuve-Rosemont Hospital Research Center
- Clémence Messmer
- Department of Biochemistry and Molecular Medicine, University of Montréal
- Nazar Mashtalir
- Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Haithem Barbour
- Maisonneuve-Rosemont Hospital Research Center
- Louis Masclef
- Department of Biochemistry and Molecular Medicine, University of Montréal
- Marion Voide
- Maisonneuve-Rosemont Hospital Research Center
- Claire Viallard
- Maisonneuve-Rosemont Hospital Research Center
- Salima Daou
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Djaileb Abdelhadi
- Department of Biochemistry and Molecular Medicine, University of Montréal
- Daryl Ronato
- CHU de Québec Research Center, Oncology Division
- Mohammadjavad Paydar
- Institute for Research in Immunology and Cancer (IRIC), University of Montréal
- Anaïs Darracq
- Maisonneuve-Rosemont Hospital Research Center
- Karine Boulay
- Maisonneuve-Rosemont Hospital Research Center
- Nicolas Desjardins-Lecavalier
- Maisonneuve-Rosemont Hospital Research Center
- Przemyslaw Sapieha
- Maisonneuve-Rosemont Hospital Research Center
- Jean-Yves Masson
- CHU de Québec Research Center, Oncology Division
- Mikhail Sergeev
- Maisonneuve-Rosemont Hospital Research Center
- Benjamin H. Kwok
- Department of Medicine, University of Montréal
- Laura Hulea
- Maisonneuve-Rosemont Hospital Research Center
- Frédérick A. Mallette
- Maisonneuve-Rosemont Hospital Research Center
- Eric Milot
- Maisonneuve-Rosemont Hospital Research Center
- Bruno Larrivée
- Maisonneuve-Rosemont Hospital Research Center
- Hugo Wurtele
- Maisonneuve-Rosemont Hospital Research Center
- El Bachir Affar
- Maisonneuve-Rosemont Hospital Research Center
- DOI
- https://doi.org/10.1038/s41467-021-27306-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient replenishment.
