Jichu yixue yu linchuang (Dec 2020)

Antibiotic resistance of Helicobacter pylori:a multicenter prospective analysis

  • YE Shan-shan, LI Jun-da, ZHOU Ying-sheng, LIU Lu, WU Jian-wei, LYU Zhi-wu, LIU Jin-tao

Journal volume & issue
Vol. 40, no. 12
pp. 1661 – 1665

Abstract

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Objective To investigate the infection of Helicobacter pylori (Hp) and its resistance to six kinds of antibiotics in Shenzhen. Methods Urease test and Hp cultivation were performed in 5 080 patients with gastrointestinal discomfort in three hospitals in Shenzhen, and antibiotic sensitivity test of agar dilution was performed. Results Among the 5 080 patients, a total of 3 203 patients were Hp positive, with a positive rate of 63.05%. The resistance rate of 3 203 Hp strains to antibiotics was metronidazole (MNZ)(99.6%),amoxicillin(AMX)(30.5%),clarithromycin(CAM)(10.6%), doxycycline (DOX) (0.3%), furazolidone(FR) (0.2%), and levofloxacin(LVX) (0.1%). The rates of total sensitivity to Hp was 0.18%, single drug resistance, double and multiple drug resistance were 62.06%, 33.94% and 3.81%, respectively. MNZ and AMX had the highest double drug resistance (26.69%), while MNZ, CAM and AMX had the highest triple drug resistance (3.68%). The age ≤40 years seems to be a factor for single antibiotic resistance, while the age ＞40 years is a risk factor for double antibiotic resistance of Hp strain. Gender is an influence factor of Hp strain on CAM and single and double antibiotic resistance. Conclusions Hp has a high infection rate and high resistance to MNZ, followed by AMX and CAM.

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