Nature Communications (Mar 2016)

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

  • Anil Noronha Antony,
  • Melanie Paillard,
  • Cynthia Moffat,
  • Egle Juskeviciute,
  • Jason Correnti,
  • Brad Bolon,
  • Emanuel Rubin,
  • György Csordás,
  • Erin L. Seifert,
  • Jan B. Hoek,
  • György Hajnóczky

DOI
https://doi.org/10.1038/ncomms10955
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regeneration and postnatal adaptation-associated stress.