Cutaneous Human Papillomavirus E7 Type-Specific Effects on Differentiation and Proliferation of Organotypic Skin Cultures

K. Westphal; B. Akgül; A. Storey; I. Nindl

doi:10.3233/CLO-2009-0476

Cellular Oncology (Jan 2009)

Cutaneous Human Papillomavirus E7 Type-Specific Effects on Differentiation and Proliferation of Organotypic Skin Cultures

K. Westphal,
B. Akgül,
A. Storey,
I. Nindl

Affiliations

K. Westphal: Department of Dermatology, Venereology and Allergy, Charité, Skin Cancer Center Charité, University Hospital of Berlin, Berlin, Germany
B. Akgül: Cancer Research UK, Skin Tumour Laboratory, ICMS, London, UK
A. Storey: Cancer Research UK, Skin Tumour Laboratory, ICMS, London, UK
I. Nindl: Department of Dermatology, Venereology and Allergy, Charité, Skin Cancer Center Charité, University Hospital of Berlin, Berlin, Germany

DOI: https://doi.org/10.3233/CLO-2009-0476
Journal volume & issue: Vol. 31, no. 3
pp. 213 – 226

Abstract

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Background: A role for cutaneous human β-papillomavirus (HPV) types as co-factors in the development of non-melanoma skin cancer has been postulated. Here we have investigated the effects of E7 expression on keratinocyte differentiation, proliferation and cell-cycle proteins in organotypic skin cultures.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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