Molecules (Aug 2013)

Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen

  • Tao Wang,
  • Xiu-Mei Gao,
  • Kojo Agyemang,
  • Li-Li Liu,
  • Kaunda Joseph Sakah,
  • Zhi-Zhen Wu,
  • Yi Zhang,
  • Li-Feng Han

DOI
https://doi.org/10.3390/molecules180910352
Journal volume & issue
Vol. 18, no. 9
pp. 10352 – 10366

Abstract

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Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.

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