Parietal conditioning enhances motor surround inhibition

Nivethida Thirugnanasambandam; Giorgio Leodori; Traian Popa; Panagiotis Kassavetis; Alexandra Mandel; Alexander Shaft; Jaron Kee; Sarung Kashyap; Gregg Khodorov; Mark Hallett

Brain Stimulation (Mar 2020)

Parietal conditioning enhances motor surround inhibition

Nivethida Thirugnanasambandam,
Giorgio Leodori,
Traian Popa,
Panagiotis Kassavetis,
Alexandra Mandel,
Alexander Shaft,
Jaron Kee,
Sarung Kashyap,
Gregg Khodorov,
Mark Hallett

Affiliations

Nivethida Thirugnanasambandam: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA
Giorgio Leodori: IRCCS NEUROMED, Pozzilli, Italy
Traian Popa: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA
Panagiotis Kassavetis: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA
Alexandra Mandel: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA; The George Washington University, Washington, D.C, USA
Alexander Shaft: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA; University of Nevada School of Medicine, Reno, NV, USA
Jaron Kee: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA; University of New Mexico School of Medicine, Albuquerque, NM, USA
Sarung Kashyap: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA
Gregg Khodorov: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA; The George Washington University, Washington, D.C, USA
Mark Hallett: Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA; Corresponding author. Human Motor Control Section, NINDS, NIH, Bethesda, MD, USA.

Journal volume & issue: Vol. 13, no. 2
pp. 447 – 449

Abstract

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Background: Motor surround inhibition (mSI) is a phenomenon supportive for executing selective finger movements, wherein synergist muscles are selectively facilitated while surround muscles are inhibited. Previous studies of conditioning inputs to several intracortical and cortico-cortical inhibitory networks did not show an influence on mSI. The inhibitory posterior parietal-motor network, which is crucial for executing fine movements, however, has not been studied. Objective/hypothesis: To investigate the role of inhibitory posterior parietal-motor network in mSI. We hypothesized that conditioning this inhibitory network would enhance mSI. Methods: 11 healthy adults completed study. mSI was elicited by applying a TMS pulse over the motor cortex coupled with or without a conditioning input to an inhibitory spot in the posterior parietal cortex at 2 or 4 ms interval. Results: Conditioning input to the posterior parietal cortex increased mSI by ∼20% Conclusion: The inhibitory posterior parietal-motor network appears to contribute to the genesis of mSI.

Published in Brain Stimulation

ISSN: 1935-861X (Print); 1876-4754 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-stimulation

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