Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> Nematodes
Marta Ziaja-Sołtys,
Przemysław Kołodziej,
Dawid Stefaniuk,
Anna Matuszewska,
Magdalena Jaszek,
Anna Bogucka-Kocka
Affiliations
Marta Ziaja-Sołtys
Chair and Department of Biology with Genetics, Medical University of Lublin, Witolda Chodźki Street 4A, 20-093 Lublin, Poland
Przemysław Kołodziej
Chair and Department of Biology with Genetics, Medical University of Lublin, Witolda Chodźki Street 4A, 20-093 Lublin, Poland
Dawid Stefaniuk
Department of Biochemistry, Maria Curie-Skłodowska University, Akademicka Street 19, 20-033 Lublin, Poland
Anna Matuszewska
Department of Biochemistry, Maria Curie-Skłodowska University, Akademicka Street 19, 20-033 Lublin, Poland
Magdalena Jaszek
Department of Biochemistry, Maria Curie-Skłodowska University, Akademicka Street 19, 20-033 Lublin, Poland
Anna Bogucka-Kocka
Chair and Department of Biology with Genetics, Medical University of Lublin, Witolda Chodźki Street 4A, 20-093 Lublin, Poland
Plants and fungi are known as a valuable source of natural medicines used in the treatment of various diseases. Many of them are used to treat human and animal gastrointestinal diseases caused by parasites. The aim of this study was to investigate for the first time the antinematode properties of extracellular low-molecular subfractions (ex-LMS) obtained from the liquid growth medium of idiophasic Cerrena unicolor cultures. The fungal fractions were isolated according to a procedure previously described by Jaszek et al. The in vitro tests were performed using nematodes of the Rhabditis genus. As demonstrated by the results, the total fraction with a molecular weight C. unicolor may be a good new candidate for research on nematode infections.
