Frontiers in Oncology (Oct 2021)
Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study
- Ming Yang,
- Ming Yang,
- Ming Yang,
- Ming Yang,
- Qi Zhang,
- Qi Zhang,
- Qi Zhang,
- Qi Zhang,
- Guo-Tian Ruan,
- Guo-Tian Ruan,
- Guo-Tian Ruan,
- Guo-Tian Ruan,
- Meng Tang,
- Meng Tang,
- Meng Tang,
- Meng Tang,
- Xi Zhang,
- Xi Zhang,
- Xi Zhang,
- Xi Zhang,
- Meng-Meng Song,
- Meng-Meng Song,
- Meng-Meng Song,
- Meng-Meng Song,
- Xiao-Wei Zhang,
- Xiao-Wei Zhang,
- Xiao-Wei Zhang,
- Xiao-Wei Zhang,
- Kang-Ping Zhang,
- Kang-Ping Zhang,
- Kang-Ping Zhang,
- Kang-Ping Zhang,
- Yi-Zhong Ge,
- Yi-Zhong Ge,
- Yi-Zhong Ge,
- Yi-Zhong Ge,
- Yi-Zhong Ge,
- Han-Ping Shi,
- Han-Ping Shi,
- Han-Ping Shi,
- Han-Ping Shi
Affiliations
- Ming Yang
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Ming Yang
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Ming Yang
- Department of Oncology, Capital Medical University, Beijing, China
- Ming Yang
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Qi Zhang
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Qi Zhang
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Qi Zhang
- Department of Oncology, Capital Medical University, Beijing, China
- Qi Zhang
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Guo-Tian Ruan
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Guo-Tian Ruan
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Guo-Tian Ruan
- Department of Oncology, Capital Medical University, Beijing, China
- Guo-Tian Ruan
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Meng Tang
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Meng Tang
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Meng Tang
- Department of Oncology, Capital Medical University, Beijing, China
- Meng Tang
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Xi Zhang
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Xi Zhang
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Xi Zhang
- Department of Oncology, Capital Medical University, Beijing, China
- Xi Zhang
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Meng-Meng Song
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Meng-Meng Song
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Meng-Meng Song
- Department of Oncology, Capital Medical University, Beijing, China
- Meng-Meng Song
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Xiao-Wei Zhang
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Xiao-Wei Zhang
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Xiao-Wei Zhang
- Department of Oncology, Capital Medical University, Beijing, China
- Xiao-Wei Zhang
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Kang-Ping Zhang
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Kang-Ping Zhang
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Kang-Ping Zhang
- Department of Oncology, Capital Medical University, Beijing, China
- Kang-Ping Zhang
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Yi-Zhong Ge
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Yi-Zhong Ge
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Yi-Zhong Ge
- Department of Oncology, Capital Medical University, Beijing, China
- Yi-Zhong Ge
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- Yi-Zhong Ge
- Department of Cancer Radiotherapy and Chemotherapy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Han-Ping Shi
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Han-Ping Shi
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Han-Ping Shi
- Department of Oncology, Capital Medical University, Beijing, China
- Han-Ping Shi
- Laboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China
- DOI
- https://doi.org/10.3389/fonc.2021.710423
- Journal volume & issue
-
Vol. 11
Abstract
BackgroundColorectal cancer (CRC) is one of the most common malignancies throughout the world, with high rates of morbidity and mortality. Previous studies reported that serum creatinine (Scr) concentrations were associated with overall survival (OS) in cancer patients, but little is known about the association between Scr and OS in patients with CRC. This study investigated the relationship between Scr concentrations and OS in patients with CRC and examined possible effect modifiers.MethodsA retrospective cohort, including 1,733 patients with CRC, was established from a multi-center clinical study. Patients were divided into low (<71 μmol/L in men or <59 μmol/L in women), normal (71-104 μmol/L in men or 59-85 μmol/L in women) and high (>104 μmol/L in men or >85 μmol/L in women) Scr groups. Cox regression analysis was used to examine association between Scr concentrations and OS. Stratified (subgroup) analyses were used to examine men and women separately. Interaction tests were used to evaluate associations between each variable and OS, as well as possible interactions of these variables with Scr levels. Cross-classified analyses were used only in men.ResultsPatients with low [hazard ratio (HR) = 1.43, 95% confidence interval (CI) = 1.19-1.72; P < 0.001] or high (HR = 1.89, 95% CI = 1.36-2.63; P < 0.001) Scr level had a significantly lower OS than patients with normal Scr levels. Significant interactions with Scr concentrations were observed for body mass index (P for interaction = 0.019) in men.ConclusionLow or high Scr concentration is associated with significantly lower OS in patients with CRC. Future study is warranted to investigate the underlying mechanism.
Keywords
