Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B
Vrushali P. Abhyankar,
Amber M. Bates,
Carol L. Fischer,
Georgia K. Johnson,
Janet M. Guthmiller,
Ann Progulske-Fox,
Kim A. Brogden
Affiliations
Vrushali P. Abhyankar
Department of Periodontology, University of Tennessee, College of Dentistry, TN 38163, USA
Amber M. Bates
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA
Carol L. Fischer
Department of Biology, Waldorf University, Forest City, IA 50436, USA
Georgia K. Johnson
Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
Janet M. Guthmiller
College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
Ann Progulske-Fox
Center for Molecular Microbiology and Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
Kim A. Brogden
Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA; Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA; Corresponding author at: Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, N423 DSB, 801 Newton Road, Iowa City, IA 52242, USA.
Chemokines and cytokines produced in gingival tissues exposed to microorganisms and microbial products in dental plaque lead to local inflammation and tissue damage seen in periodontal disease. Bates et al. 2018 [1] reported that Porphyromonas gingivalis hemagglutinin B (HagB)-induced matrix metalloproteinase (MMP) responses of single cell cultures containing dendritic cells, gingival epithelial (GE) keratinocytes, or T cells were significantly different from the MMP responses of these same cells grown in multi-cell cultures. Here we report the concentrations (pg/ml) of HagB-induced IL1α, IL6, IL8, IL12(p40), GM-CSF, MIP1α, MIP1β, RANTES, TNFα, and VEGF produced by dendritic cells, GE keratinocytes, or T cells in single cell cultures, two-cell cultures, or three-cell cultures. Keywords: Cytokines, Periodontal disease, Dendritic cells, Keratinocytes, T cells, Porphyromonas gingivalis, Hemagglutinin B
