The Level of C-Reactive Protein in the Blood Plasma of Young Adults with Childhood-Onset Growth Hormone Deficiency

Abstract

The article presents the data on the level of high-sensitivity C-reactive protein in the blood plasma of young adults with growth hormone deficiency that occurred in childhood and persists in adulthood. It was found that prolonged deficiency of endogenous growth hormone is associated with a significant increase of C-reactive protein level in the blood plasma of patients. This could significantly enhance the risk of early atherosclerosis and cardiovascular diseases in patients with growth hormone deficiency already at a young age. Therapy with recombinant growth hormone preparations leads to normalization of C-reactive protein levels already in 3–6 months after therapy initiation/retreatment.

Keywords

• growth hormone deficiency
• C-reactive protein
• recombinant growth hormone therapy